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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE4B
All Species:
18.18
Human Site:
Y405
Identified Species:
44.44
UniProt:
Q07343
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07343
NP_001032416.1
736
83343
Y405
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
Chimpanzee
Pan troglodytes
XP_001162426
729
82535
Y398
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
Rhesus Macaque
Macaca mulatta
XP_001091102
736
83341
Y405
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
Dog
Lupus familis
XP_536678
710
80315
V394
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01063
747
84544
Y400
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
Rat
Rattus norvegicus
P14646
736
83356
Y405
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086133
721
82347
A397
A
Y
H
N
S
L
H
A
A
D
V
T
Q
S
T
Zebra Danio
Brachydanio rerio
XP_708955
713
80958
H397
A
D
V
A
Q
S
T
H
I
L
L
S
T
P
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4S9
983
107322
F644
H
Y
V
K
D
N
P
F
H
N
S
L
H
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
R377
T
F
S
L
L
R
Q
R
N
L
F
K
T
F
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
99.5
86.8
N.A.
71.8
96.5
N.A.
N.A.
N.A.
78.5
74.5
N.A.
44.5
N.A.
44.8
N.A.
Protein Similarity:
100
98.9
99.7
89.6
N.A.
81.7
98.2
N.A.
N.A.
N.A.
85.3
83
N.A.
56.1
N.A.
60.4
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
80
100
N.A.
N.A.
N.A.
13.3
6.6
N.A.
66.6
N.A.
0
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
N.A.
N.A.
40
20
N.A.
73.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
10
20
0
0
50
10
10
0
0
0
0
70
70
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
60
0
0
0
0
10
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% E
% Phe:
0
10
0
0
0
0
0
10
0
0
10
0
0
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
60
0
60
0
0
0
20
10
60
0
0
0
60
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% I
% Lys:
0
0
0
10
0
0
0
0
0
0
0
10
0
0
0
% K
% Leu:
0
0
0
10
10
10
0
0
10
30
10
50
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
0
10
0
0
10
60
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
10
0
0
0
0
0
10
10
0
% P
% Gln:
0
0
0
10
10
0
10
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% R
% Ser:
0
0
10
40
20
10
0
0
0
0
60
10
0
10
0
% S
% Thr:
10
0
0
0
0
10
10
0
0
0
0
20
20
0
10
% T
% Val:
0
10
20
0
0
50
0
10
0
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
70
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _